The Scripps Research Institute Alcohol Research Center

The Scripps Research Institute ARC




Koob GF. The role of animal models in reward deficit disorders: views from academia. In: McArthur RA, Borsini F (eds) Animal and Translational Models of CNS Drug Discovery: Volume 3. Reward Deficit Disorders. Academic Press, London, 2008, pp. 59-89.

Koob GF. Neurobiology of addiction. In: Galanter M, Kleber HD (eds) Textbook of Substance Abuse Treatment, 4th edn. American Psychiatric Publishing, Washington DC, 2008, pp. 3-16.

Koob GF. A role for brain stress systems in addiction. Neuron, 2008, 59:11-34. [PMC2748830]

Koob GF, Le Moal M. Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society of London B Biological Sciences, 2008, 363:3113-3123. [PMC2607326]

Koob GF. Hedonic homeostatic dysregulation as a driver of drug-seeking behavior. Drug Discovery Today: Disease Models, 2008, 5:207-215. [PMC2801885]


Koob GF. Addiction: neurobiological mechanism. In: Squire LR (ed) Encyclopedia of Neuroscience, vol 1. Academic Press, Oxford, 2009, pp. 75-81.

Koob GF. Neurobiology of addiction. In: Cohen LM, Collins FL Jr, Young AM, McChargue DE, Leffingwell TR, Cook KL (eds) Pharmacology and Treatment of Substance Abuse: Evidence- and Outcome-Based Perspectives, Routledge, New York, 2009, pp. 85-108.

Koob GF, Simon EJ. The neurobiology of addiction: where we have been and where we are going. Journal of Drug Issues, 2009, 39:115-132. [PMC2901107]

Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology, 2009, 56:18-31. [PMC2637927]

Koob GF, Lloyd GK, Mason BJ. Development of pharmacotherapies for drug addiction: a Rosetta Stone approach. Nature Reviews Drug Discovery, 2009, 8:500-515. [PMC2760328]

Koob GF. Molecular approaches to future treatments. European Neuropsychopharmacology, 2009, 19(suppl 1):s79-s80.

Koob GF. Brain stress systems in the amygdala in addiction. Brain Research, 2009, 1293:61-75. [PMC2774745]

Koob GF. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry, 2009, 42(suppl 1):s32-s41. [PMC2748837]

Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biology, 2009, 7:70. [PMC2777866]


Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today, 2010, 15:371-383. [PMC2864802]

Koob GF, Le Moal M. The role of dopamine in the motivational vulnerability to addiction. In: Iversen LL, Iversen SD, Dunnett SB, Bjorklund A (eds) Dopamine Handbook. Oxford University Press, Oxford, 2010, pp. 371-388.

Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology Reviews, 2010, 35:217-238 [erratum: 35:1051]. [PMC2805560]

Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs, 2010, 11:63-71. [PMC2812895]

George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews, 2010, 35:232-247. [PMC2955797]

Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology, 2010, 5:393-410. [PMC2886284]

Koob GF, Le Moal M. Neurobiological mechanisms for opponent motivational processes in addiction. In: Robbins TW, Everitt BJ, Nutt DJ (eds) The Neurobiology of Addiction: New Vistas, Oxford University Press, Oxford, 2010, pp. 7-23.


Koob GF. Animal models of drug dependence: motivational perspective. In: Johnson BA (ed) Addiction Medicine: Science and Practice. Springer, New York, 2011, pp. 333-357.

Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. CNS Drugs, 2011, 25:271-287. PMID: 21425881

Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. In: Uhl GR (ed) Addiction Reviews (series title: Annals of the New York Academy of Sciences, vol 1216). New York Academy of Sciences, New York, 2011, pp. 24-40. [PMC3076900]

Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Current Topics in Behavioral Neuroscience, 2011, Jul 10. [Epub ahead of print] PubMed PMID: 21744309.


Gilpin, N. W., Karanikas, C. A., & Richardson, H. N. (2012). Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats. PLoS ONE, 7(2), e31466. doi:10.1371/journal.pone.0031466

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