The Scripps Research Institute Alcohol Research Center

The Scripps Research Institute ARC

TSRI ARC

Publications

2012—Present

Ayanwuyi L. O., Carvajal F., Lerma-Cabrera J., Domi E., Bjork K., Ubaldi M., Heilig M., Roberto M., Ciccocioppo R., Cippitelli A. (2013) Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and relapse behaviors of Marchigian Sardinian alcohol-preferring (msP) rats. Frontiers in Psychiatry, Addictive Disorders. Apr 12;4:23. PMC3624086

Bajo M., Herman M.A., Varodayan F.P., Oleata C.S., Madamba S.G., Harris R.A., Blednov Y. A., and Roberto M. (2015) Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala. Brain Behav Immun. 2015 Mar;45:189-97. doi: 10.1016/j.bbi.2014.11.011. Epub 2014 Dec 3. PMC4405101

Bajo M., Madamba S., Roberto M., Blednov Y., Sagi V., Roberts E., Rice K., Harris R. A. and Siggins G.R. (2014) Innate Immune Factors Modulate Ethanol Interactions with GABAergic Transmission in Mouse Central Amygdala. Brain, Behavior and Immunity. 2014 Mar 24. pii: S0889-1591(14)00073-7. doi: 10.1016/j.bbi.2014.03.007. [Epub ahead of print] PMC4126651

Bajo M., Mongomery S. Cates L.N., Nadav T., Cheng, K., Delucchi A., Crawford E., Yin, H., Roberts AJ., and Roberto M. (2016) Evaluation of TLR4 inhibitor, T532126, in modulation of ethanol drinking behavior in alcohol dependent mice. Alcohol Alcohol. 2016 May 5. PMID: 27151970; PMCID: PMC5004745

Bajo M., Varodayan F.P., Madamba S.G., Roberts A.J., Casal L.M., Oleata C.S, Siggins G.R., and Roberto M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala. Front Pharmacol. 2015 Mar 19;6:49. doi: 10.3389/fphar.2015.00049. eCollection 2015. PMC4365713

Bilbao, A., Serrano, A., Cippitelli, A., Pavon, F.J., Giuffrida, A., Suarez, J., Garcia-Marchena, N., Baixeras, E., Gomez de Heras, R., Ciccocioppo, R., Cravatt, B.F., Parsons, L.H., Piomelli, D., Rodriguez de Fonseca, F. (2014) Role for the satiety factor oleoylethanolamide in alcoholism. Addict Biol. 2016 Jul;21(4):859-72. doi: 10.1111/adb.12276. Epub 2015 Jun 2. PMID: 26037332; PMCID: PMC4668242

Blasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Iannotti FA, Di Marzo V, Zorrilla EP, Cottone P. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. Neuropsychopharmacology. 2013 Nov;38(12):2498-507. doi: 10.1038/npp.2013.153. PubMed PMID: 23793355; PubMed Central PMCID: PMC3799070

Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behav Brain Res. 2014 Sep 1;271:171-6. doi: 10.1016/j.bbr.2014.06.003. PubMed PMID: 24914463; PubMed Central PMCID: PMC4216724.

Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology (Berl). 2014 Mar;231(5):929-37. doi: 10.1007/s00213-013-3307-2. PubMed PMID: 24221826; PubMed Central PMCID: PMC3945412.

Buczynski M.W., Herman M.A., K. Hsu, Natividad L.A., Irimia C., Polis I.Y., Pugh H., Chang J.W., Niphakis M.J., Cravatt B.F., Roberto M., and Parsons L.H. (2016) Diacylglycerol lipase-alpha inhibits GABA release in the ventral tegmental area during chronic nicotine exposure to facilitate drug self-administration. Proc Natl Acad Sci USA. 2016 Jan 26;113(4):1086-91. doi: 10.1073/pnas.1522672113. PMID: 26755579; PMCID: PMC4743781

Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH and Cravatt BF. (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is biosteric with endocannabinoid substrates. Chemistry & Biology 19, 579-588. PMCID: PMC3361572

Ciccocioppo R., de Guglielmo G., Hansson A.C., Ubaldi M., Kallupi M., Cruz M.T., Oleata C.S., Heilig M. and Roberto M. (2014) Restraint Stress alters Nociceptin/Orphanin FQ and CRF systems in the rat central amygdala: Significance for anxiety-like behaviors. The Journal of Neuroscience, Jan8; 34(2):363-72. doi: 10.1523/JNEUROSCI.2400-13.2014. PMC3870926

Ciccocioppo R., Stopponi S., Economidou D., Kuriyama M., Kinoshita H., Heilig M., Roberto M., Weiss F., and Teshima K. (2014) Chronic administration of the brain-penetrant selective NOP receptor agonist MT- 7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology. 2014 May 27. doi: 10.1038/npp.2014.113. [Epub ahead of print] PMC4207340

Cippitelli A, Ayanwuyi LO, Barbier E, Domi E, Lerma-Cabrera JM, Carvajal F, Scuppa G, Li H, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R. (2014) Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1- R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. Psychopharmacology (Berl). 2014 Sep 27. [Epub ahead of print] PMC4339612

Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF (2014) Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One, 9(5):e97216. PMC4016270.

Contet C, Kim A, Le D, Iyengar SK, Kotzebue RW, Yuan CJ, Kieffer BL, Mandyam CD (2014) μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addict Biol. 2014 Sep;19(5):770-80. PMC3681911

Cottone P, Sabino V, Nagy TR, Coscina DV, Levin BE, Zorrilla EP. Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats. Int J Obes (Lond). 2013 Dec;37(12):1515-23. doi: 10.1038/ijo.2013.22. PubMed PMID: 23478425; PubMed Central PMCID: PMC3706508

Criado JR, Gilder DA, Kalafut MA, Ehlers CL. Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control. Clin Auton Res. 2016 Apr;26(2):87-95. doi: 10.1007/s10286-015-0333-7. Epub 2016 Jan 13.PMID: 26758567; PMC4862581

Criado, J. R., & Ehlers, C. L. (2013). Effects of adolescent onset voluntary drinking followed by ethanol vapor exposure on subsequent ethanol consumption during protracted withdrawal in adult Wistar rats. Pharmacol Biochem Behav, 103(3), 622-630. doi:10.1016/j.pbb.2012.10.016 PMC3544970

Criado JR, Gilder DA, Kalafut MA, Ehlers CL. Obesity in American Indian and Mexican American men and women: Associations with blood pressure and cardiovascular autonomic control. Cardiovascular Psychiatry and Neurology 2013; doi:10.1155/2013/680687. Epub 2013 Aug 19 PMID: 24024026; PMCID: PMC3760286

Criado JR, Gizer IR, Edenberg HJ, Ehlers CL. CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women. Twin Res Hum Genet 17(2):80-88, 2014. Doi: 10.1017/thg.2014.11 Epub 2014 Mar 3. PMID: 24588897; PMCID: PMC4064688

Cruz M.T., Herman M., Kallupi M. and Roberto M. (2012) Nociceptin/orphanin FQ blockade of the CRF-induced GABA Release in the Central Amygdala is enhanced after chronic ethanol treatment. Biological Psychiatry 2012 Apr 15;71(8):666-76. PMID: 22153590 PMCID: PMC3838304

Cruz M.T., Herman M.A. Cote D.M., Ryabinin A.E. and Roberto M. Ghrelin Increases GABAergic Transmission and Interacts with Ethanol Actions in the Rat Central Nucleus of the Amygdala (2013). Neuropsychopharmacology. Jan;38(2):364-75. Epub 2012 Sep 12. PMCID: PMC3527109

Cui C., Noronha A., Koob G.F, Sinha R., Thakkar M., Matochik J., Crews F., Chandler L. J, Pfefferbaum A, Becker H., Lovinger D., Everitt B., Egli M., Mandyam C., Fein G., Potenza M.N., Harris R. A., Grant K.A., Roberto M., Meyerhoff D.J., Sullivan E.V. Brain Pathways to Recovery from Alcohol Dependence. Alcohol. 2015 Aug;49(5):435-52. doi: 10.1016/j.alcohol.2015.04.006. Epub 2015 May 14. PMC4468789

Cui C., Noronha A., Morikawa H., Alvarez V.A., Stuber G., Szumlinski K.K., Kash T.L., Roberto M. and Wilcox M. (2012) New Insights on Neurobiological Mechanisms underlying Alcohol Addiction. Neuropharmacology, 13;67C:223-232. PMC3562413

de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016. PMID: 27605618; PMCID: PMC5013191

Edwards S, Baynes BB, Carmichael CY, Zamora-Martinez ER, Barrus M, Koob GF, Gilpin NW. Traumatric stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Translational Psychiatry, 2013, 3:e296. PMC3756295

Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behavioural Pharmacology, 2013, 24:356-362. NIHMS: 536851; PMID: 23839030 PMCID: PMC3866817

Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. In: Kobeissy H (ed) Psychiatric Disorders: Methods and Protocols (series title: Methods in Molecular Biology, vol 829). Springer, New York, 2012, pp. 31-48. PMC3285446

Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF1 receptor antagonism. Neuropharmacology, 2012, 62:1142-1151. PMC3262951

Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews, 2012, 36:2179-2192. PMC3612891

Ehlers CL, Kim C, Gilder DA, Stouffer GM, Caetano R, Yehuda R. Lifetime history of traumatic events in a young adult Mexican American sample: relationship to substance dependence, affective disorder, acculturation and PTSD. J. Psychiatric Res. 83:79-85, 2016. doi:10.1016/j.psychires.2016.08.009. [Epub ahead of print] PMID: 27569652, NIHMS 813737, PMCID: PMC5107155

Ehlers CL, Liang T, Gizer IR. ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. Am J of Drug and Alcohol Abuse 38(5):389-394, 2012. PMID: 22931071; PMCID: PMC3498484

Ehlers CL, Stouffer GM, Corey L, Gilder DA. The clinical course of DSM-5 alcohol use disorders in young adult native and Mexican Americans. Am J Addict. 2015 Dec;24(8):713-21. doi: 10.1111/ajad.12290. PubMed PMID: 26346282; PubMed Central PMCID: PMC4715470.

Ehlers CL, Stouffer GM, Gilder DA. Associations between a history of binge drinking during adolescence and self reported responses to alcohol in young adult Native and Mexican Americans. Alcohol Clin Exp Res. 2014 Jun 24. doi: 10.1111/acer.12466. [Epub ahead of print] PMID: 24961146; NIHMS 589973; PMCID: PMC4125016

Francesconi W, Sánchez-Alavez M, Berton F, Alboni S, Benatti C, Mori S, Nguyen W, Zorrilla E, Moroncini G, Tascedda F, Conti B. The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis. J Neurosci. 2016 May 4;36(18):5170-80. doi: 10.1523/JNEUROSCI.3919-15.2016. PubMed PMID: 27147667.

Frihauf JB, Fekete EM, Nagy TR, Levin BE, Zorrilla EP. Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers. Am J Physiol Regul Integr Comp Physiol. 2016 Sep 21:ajpregu.00023.2016. doi: 10.1152/ajpregu.00023.2016. [Epub ahead of print] PubMed PMID: 27654396.

George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology and Behavior, 2012, 106:58-64. PMC3288230

George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences USA, 2012, 109:18156-18161. PMC3497825

Gilpin N.W. and Roberto M. (2012) Neuropeptide Modulation of Central Amygdala Neuroplasticity is a Key Mediator of Alcohol Dependence. Neuroscience and Biobehavioral Reviews. Feb;36(2):873-88. PMCID: PMC3325612

Gilpin N.W., Herman M.A. and Roberto M. (2014) The central amygdala as an integrative hub for anxiety and alcohol use disorders. Biol Psychiatry. 2015 May 15;77(10):859-69. doi: 10.1016/j.biopsych.2014.09.008. Epub 2014 Sep 22. PMC4398579

Gilpin, N.W., Roberto M., Koob, G.F. and Schweitzer, P. (2014) Kappa Opioid Receptor Activation Decreases Inhibitory Transmission and Antagonizes Alcohol Effects in Rat Central Amygdala. Neuropharmacology. 2014 Feb;77:294-302. doi: 10.1016/j.neuropharm.2013.10.005. Epub 2013 Oct 21. PMC3873141

Grieder TE, Herman M, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Canonigo V, Sanna P, Tapper A, Roberto M, Kieffer BL, Sawchecko PE, Koob GF, van der Kooy D, George O (2014) CRF neurons in the ventral tegmental area control the aversive effects of nicotine withdrawal and promote escalation of nicotine intake; Nature Neurosci., 2014 Dec; 17 (12): 1751-58. PMC4241147

Herman M.A and Roberto M. (2014) Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol. Addiction Biology, Aug 29. doi: 10.1111/adb.12181. [Epub ahead of print] PMC4345144

Herman M.A, Kallupi K., Luu G., Oleata C.S, Koob G.F., Heilig M., Ciccocioppo R. and Roberto M. (2013) Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology, 4;67C:337-348, PMID: 23220399 PMC3562384

Herman M.A, Varodayan F., Oleata C.S, Kirson D., Luu G., Heilig M., Ciccocioppo R. and Roberto M. (2015) Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects. Neuropharmacology. 2016 Mar;102:21-31. doi: 10.1016/j.neuropharm.2015.10.027. Epub 2015 Oct 28. PMID: 26519902 PMCID: PMC4698227

Herman M.A., Contet C. and Roberto M. A functional switch in tonic GABA currents alters the output of central amygdala CRF receptor-1 neurons following chronic ethanol exposure. J Neurosci. 2016 Oct 19;36(42):10729-10741. PMID: 27798128 DOI: 10.1523/JNEUROSCI.1267-16.2016 PMCID In Process

Herman M.A., Contet C., Justice N.J., Vale W. and Roberto M. (2013) Subunit-specific tonic GABA currents and differential effects of ethanol within the central amygdala circuitry of CRF1 reporter mice. The Journal of Neuroscience, 20;33(8):3284-98. PMC3711798.

Herman M.A., Sidhu H., Stouffer D.G., Kreifeldt M., Le D., Cates-Gatto C., Munoz M.B., Roberts A.J., Parsons L.H., Roberto M., Wickmand K., Slesinger P.E. and Contet C. (2015) GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7091-6. doi: 10.1073/pnas.1416146112. Epub 2015 May 11. PMC4460485

Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology, 2013, 67:337-348. PMC3562384

Higley AE, Koob GF, Mason BJ. Treatment of alcohol dependence with drug antagonists of the stress response. Alcohol Res. 2012;34(4):516-21. PMID: 23584117; PMC3860394

Irimia, C., Polis, I.Y., Wiskerke, J., de Vries, T.J., Pattij, T., Parsons, L.H. (2015) Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence. Addict Biol. 2015 Mar;20(2):263-74. doi: 10.1111/adb.12119. Epub 2013 Dec 17. PMID: 24341858 PMCID: PMC4061283 DOI: 10.1111/adb.12119

Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep;19(5):755-7. doi: 10.1111/adb.12059. PubMed PMID: 23639035; PubMed Central PMCID: PMC3872251.

Kallupi M., Oleata C.S., Luu G., Teshima K., Ciccocioppo R., Roberto M. (2014) MT-7716, a novel selective N/OFQ receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala. Frontiers in Integrative Neuroscience, Feb 18;8:18. doi: 10.3389/fnint.2014.00018. eCollection 2014. PMC3927450

Kallupi M., Varodayan F., Oleata C.S., Correia D., Luu G. and Roberto M. (2013) Nociceptin/ orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naïve and ethanol-depended rats. Neuropsychopharmacology, Oct 30. doi: 10.1038/ npp.2013.308. [Epub ahead of print] PMC3957102

Kallupi M., Wee S., Edwards S., Whitfield T.W., Oleata C.S., Luu G., Schmeichel B.E., Koob G.F. and Roberto M. (2013) Kappa Opioid Receptor-Mediated Dysregulation of GABAergic Transmission in the Central Amygdala in Cocaine Addiction. Biol Psychiatry. 2013 Oct 1;74(7):520-8. doi: 10.1016/j.biopsych.2013.04.028. Epub 2013 Jun 14. PMC3773286

Kim A, Zamora-Martinez ER, Edwards S and Mandyam CD (2014) Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. Brain Structure and Function, Brain Struct Funct. 2015;220(3):1705-20. doi: 10.1007/s00429-014-0755-3. Epub 2014 Mar 26. PMID: 24667898 PMCID: PMC4177030

Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan;76 Pt B:370-82. doi: 10.1016/j.neuropharm.2013.05.024. Review. PubMed PMID: 23747571; PubMed Central PMCID: PMC3830720.

Koob GF, Mason BJ. Existing and Future Drugs for the Treatment of the Dark Side of Addiction. Annu Rev Pharmacol Toxicol. 2016;56:299-322. PMID: 26514207

Koob GF, Zorrilla EP. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology. 2012 Jan;37(1):308-9. doi: 10.1038/npp.2011.213. PubMed PMID: 22157874; PubMed Central PMCID: PMC3238086

Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction: alcohol addiction as a reward deficit disorder. In: Sommer WH, Spanagel R (eds) Behavioral Neurobiology of Alcohol Addiction (series title: Current Topics in Behavioral Neuroscience, vol 13), Springer-Verlag, Berlin, 2012, pp. 3-30. PMC3448980

Kreifeldt M, Cates-Gatto C, Roberts AJ, Contet C (2015) BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure. Alcohol Clin Exp Res, 39(12):2394-402. PMC4712106.

Kreifeldt M, Le D, Treistman SN, Koob GF, Contet C (2013) BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Front Integr Neurosci, 7:105. PMC3874544.

Leao R, Cruz F, Vendruscolo L, de Guglielmo G, Logrip M, Planeta C, Hope B, Koob G, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. Journal of Neuroscience, 2015, 35:6241-6253. PMC4397613

Logrip M.L., Oleata C.S. and Roberto M. (2016) Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction. In Press in Neuropharmacology. DOI: 10.1016/j.neuropharm.2016.11.021 PMC in Progress.

Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology. 2014 Jun;39(7):1722-31. doi: 10.1038/npp.2014.20. Epub 2014 Jan 29. PMID: 24549104 PMCID: PMC4023146

Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 2012 Feb;62(2):552-64. doi: 10.1016/j.neuropharm.2011.07.007. Review. PubMed PMID: 21782834; PubMed Central PMCID: PMC3206986.

Logrip ML, Zorrilla EP. Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Front Integr Neurosci. 2014 Apr 8;8:30. doi: 10.3389/fnint.2014.00030. eCollection 2014. PMID: 24782725 PMCID: PMC3986522

Logrip ML, Zorrilla EP. Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A. Addict Biol. 2012 Sep;17(5):920-33. doi: 10.1111/j.1369-1600.2012.00460.x. PubMed PMID: 22741603; PubMed Central PMCID: PMC3444642.

Mandyam CD, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends Neurosci. 2012 Apr;35(4):250-60. doi: 10.1016/j.tins.2011.12.005. Epub 2012 Jan 19. PMID: 22265158 PMCID: PMC3321119

Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2015 Oct 8. pii: S0006-3223(15)00817-3. doi: 10.1016/j.biopsych.2015.09.020. [Epub ahead of print] PMID: 26592463 PMCID: PMC4826329 [Available on 2017-04-08]

Mandyam CD. The interplay between the hippocampus and amygdala in regulating aberrant hippocampal neurogenesis during protracted abstinence from alcohol dependence Front Psychiatry. 2013 Jun 27;4:61. doi: 10.3389/fpsyt.2013.00061. Print 2013. PMID: 23818882 PMCID: PMC3694261

Mason BJ, Goodell V, Shadan F. Gabapentin treatment for alcohol dependence—reply. JAMA Intern Med. 2014;174(7):1201-2. doi: 10.1001/jamainternmed.2014.1591. PMID: 25003890 Mason BJ, Higley AE. A translational approach to novel medication development for protracted abstinence. Curr Top Behav Neurosci. 2013;13:647-70. doi: 10.1007/7854_2012_201. PMID: 22351425

Mason BJ, Lehert P. Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data. Alcohol Clin Exp Res. 2012;36(3):497-508. doi: 10.1111/j.1530-0277.2011.01616.x. Epub 2011 Sep 6. PMID: 21895717; PMCID: PMC3288465

Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014;174(1):70-7. doi: 10.1001/jamainternmed.2013.11950. PMID: 24190578; PMCID: PMC3920987 Mason BJ. Acamprosate, alcoholism, and abstinence. J Clin Psychiatry. 2015;76(2):e224-5. doi: 10.4088/JCP.14com09632. PMID: 25742214

Melroy-Greif WE, Wilhelmsen KC, Ehlers CL. Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans. Drug Alcohol Depend, 2016 Sep 1;166:249-53. PMID: 27394933, PMC4983484

Montane-Jaime LK, Shafe S, Liang T, Wills DN, Berg GI, Ehlers CL. Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago. J Stud Alcohol Drugs 2014 Sept75(5)827-38 PMID: 25208201 PMCID: PMC4161702

Navarro AI, Mandyam CD. Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience. 2015 May 7;293:35-44. doi: 10.1016/j.neuroscience.2015.02.043. PubMed PMID: 25732140; PubMed Central PMCID: PMC4385447.

Nimitvilai S., Herman H., You C., Arora D.S., McElvain M.A., Roberto M. and Brodie M.S. (2014) Dopamine D2 receptor desensitization by dopamine or corticotropin releasing factor in ventral tegmental area neurons is associated with increased glutamate release. Neuropharmacology. Mar 19;82C:28-40. doi: 10.1016/j.neuropharm.2014.03.006. [Epub ahead of print] PMC4038332

Niphakis M, Cognetta A, Chang JW, Buczynski M, Parsons LH, Byrne F, Burston J, Chapman V and Cravatt, B. (2013) Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chemical Neuroscience, 4, 1322-1332 PMCID: PMC3778430

Norden-Krichmar TM, Gizer IR, Phillips E, Wilhelmsen KC, Schork NJ, Ehlers CL. Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. Twin Res Hum Genet. 2015 Dec;18(6):727-37. doi: 10.1017/thg.2015.77. PubMed PMID: 26608796; PubMed Central PMCID: PMC4727900.

Parsons LH and Hurd YL. (2015) Endocannabinoid signaling in reward and addiction. Nature Reviews Neuroscience 16, 579-594. PMCID: PMC4652927.

Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP. Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiol Behav. 2012 Sep 10;107(2):231-42. doi: 10.1016/j.physbeh.2012.06.017. PubMed PMID: 22776620; PubMed Central PMCID: PMC3825516

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